ea0090p2 | Adrenal and Cardiovascular Endocrinology | ECE2023
Imene Hani
, Thi An VU
, Riwan Brillet
, Julie Perrot
, Bouligand Jerome
, Justine Guegan
, Cherradi Nadia
, Kamenicky Peter
, Marc Lombes
, Laetitia Martinerie
, Viengchareun Say
The Mineralocorticoid Receptor (MR, NR3C2) mediates sodium-retaining action of aldosterone. Recently, we have shown that the physiological sodium loss observed in newborns in their first days of life is due to a low renal MR expression. However, the underlying molecular mechanisms remain unknown to date. In the adult renal KC3AC1 cell line, we demonstrated that variations in extracellular tonicity, which exist in the nephron, modulate MR expression by posttranscriptio...